Anti-neurodegenerative activities of aqueous extract from propolis were investigated. The aqueous extracts showed strong antioxidant activities in malondialdehyde (MDA) assay, and it effectively inhibited lipid peroxidation. In addition, the aqueous extract presented protective effects against H2O2-induced neurotoxicity in a dose-dependent manner. Our study verified that the aqueous extract has strong antioxidant activity and neuronal cell protective effect which is correlated with its total phenolics (290.75 mg GAE/g) including p-coumaric acid, vanillic acid and gallic acid. These phenolics of propolis may reduce the risk of neurodegenerative disorders, and can be utilized as effective and safe resources of functional food.

• Chang-Ho Jeong(Wooyang Frozen Food Co., Ltd.)
• Hee-Rok Jeong(Dept. of Food Science & Technology(Insti. of Agric. & Life Sci.), Gyeongsang National Univ.)
• Dae-Ok Kim(Dept. of Food Science & Biotechnology(Insti. of Life Sci. and Resources), Kyung Hee Univ.)
• Sung-Gil Choi(Dept. of Food Science & Technology(Insti. of Agric. & Life Sci.), Gyeongsang National Univ.)
• Ki-Hwan Shim(Dept. of Food Science & Technology(Insti. of Agric. & Life Sci.), Gyeongsang National Univ.)
• Ho Jin Heo(Dept. of Food Science & Technology(Insti. of Agric. & Life Sci.), Gyeongsang National Univ., Division of Applied & Life Sci.(BK21), Gyeongsang National Univ.) Corresponding author