Improved One-pot Regioselective Synthesis of 3,7-Diarylpyrazolo[1,5-α]pyrimidines and Their CB1R Activity

Yong Deog Hong; Kyoung Hee Byoun; Miyoung Park; Jun Seong Park; Song Seok Shin

논문 상세보기

Improved One-pot Regioselective Synthesis of 3,7-Diarylpyrazolo[1,5-α]pyrimidines and Their CB1R Activity KCI 등재

3,7-Diarylpyrazolo[1,5-α]pyrimidines의 개선된 One-pot Regioselective 합성과 CB1R 활성

Yong Deog Hong, Kyoung Hee Byoun, Miyoung Park, Jun Seong Park, Song Seok Shin

언어ENG
URLhttps://db.koreascholar.com/Article/Detail/302072

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대한화장품학회지 (Journal of the society of cosmetic scientists of korea)

제41권 2호 (2015.06)
pp.143-150

대한화장품학회 (The Society of Cosmetic Scientists of Korea)

초록

본 연구는 3,7-diarylpyrazolo [1,5-α]pyrimidines의 효과적인 one-pot regioselective 합성을 보여준다. 더욱이, 그 유도체는 뛰어난 CB1R 저해 활성을 나타냈다. 3,7-position에 diaryl group이 치환된 pyrazolo [1,5-α]pyrimidine은 CB1R 후보로서 가능성 있는 pharmacophore이다.

This study demonstrates an effective one-pot regioselective synthesis of 3,7-diarylpyrazolo [1,5-α]pyrimidines. Moreover, the derivatives obtained were effective CB1R antagonists. These pyrazolo [1,5-α]pyrimidines with diaryl groups at the 3,7-positions are potential pharmacophores for CB1R candidates.

키워드

aminopyrazoles aryl ketoesters regioselective synthesis 3 7-diarylpyrazolo[1 5-α]pyrimidines

저자

Yong Deog Hong(Amorepacific Corporation R&D Unit) | 홍용덕 주저자
Kyoung Hee Byoun(Amorepacific Corporation R&D Unit) | 변경희
Miyoung Park(Amorepacific Corporation R&D Unit) | 박미영
Jun Seong Park(Amorepacific Corporation R&D Unit) | 박준성
Song Seok Shin(Amorepacific Corporation R&D Unit) | 신송석 주저자

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