With the increasing trend of global trades and protection of agro-ecosystem in importing and exporting countries, quarantine and pre-shipment(QPS) fumigation for perishable commodities are critical in terms of quality maintenance of fumigated commodities as well as eradicating quarantine pest. There are limited use of methyl bromide(MB) fumigation on fruits and vegetables due to not only worker safety issue at low temperature condition but phytotoxic damage to valuable commodities. We are here presented that commercial development of methyl bromide (MB) alternatives such as ethyl formate and phosphine gas formulated with carbon dioxide, that are increasing consumer and worker safety and avoiding phytotoxic damage in routine MB fumigation.