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Learning and Memory Effect of Syringic Acid on Amyloid-β-induced Neurotoxicity in ICR Mice KCI 등재

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  • URLhttps://db.koreascholar.com/Article/Detail/306386
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농업생명과학연구 (Journal of Agriculture & Life Science)
경상대학교 농업생명과학연구원 (Institute of Agriculture & Life Science, Gyeongsang National University)
초록

To investigate the in vivo cognitive effects of syringic acid(SA), Y-maze and passive avoidance tests were performed in amyloid-β(Aβ)-induced cytotoxicity. Learning and memory impairment by Aβ neurotoxicity was partially recovered in Institute of Cancer Research(ICR) mice orally administered SA(10mg/kg of body weight). The SA treated group showed an inhibitory effect on acetylcholinesterase(AChE) that was extracted from mice brain tissue after in vivo tests. Aβ-induced oxidative stress was also examined by malondialdehyde(MDA) and 2',7,-dichlorofluorescein diacetate(DCF-DA) assays, and lipid peroxidation of brain homogenates and cellular oxidative stress were reduced by SA. In cell viability assays using 3-[4,5-dimethythiazol-2-yl]-2,5-diphenyl tetrazolium bromide(MTT), lactate dehydrogenase(LDH) leakage, and caspase 3/7 activity, the SA treated group showed relatively effective protection against Aβ-induced neurotoxicity compared to the others. Consequently, these results suggest that SA in black soybean seed coat extract might improve cognitive function because of its neuronal cell protective effects against oxidative stress and the inhibitory effect of AChE as a cholinergic enzyme.

저자
  • Ji Hee Jeong(Division of Applied Life Science(BK21 plus)(Insti. of Agric. and Life Sci.), Gyeongsang National Univ., Gyeongsangnamdo Agricultural Research and Extension Service)
  • Tae Wan Seung(Division of Applied Life Science(BK21 plus)(Insti. of Agric. and Life Sci.), Gyeongsang National Univ.)
  • Seon Kyeong Park(Division of Applied Life Science(BK21 plus)(Insti. of Agric. and Life Sci.), Gyeongsang National Univ.)
  • Chang Hyeon Park(Division of Applied Life Science(BK21 plus)(Insti. of Agric. and Life Sci.), Gyeongsang National Univ.)
  • Dong Eun Jin(Division of Applied Life Science(BK21 plus)(Insti. of Agric. and Life Sci.), Gyeongsang National Univ.)
  • Ho Jin Heo(Division of Applied Life Science(BK21 plus)(Insti. of Agric. and Life Sci.), Gyeongsang National Univ.) Corresponding author