Mushroom have long been valued as highly nutritious and tasty foods in many societies throughout the world. Itis known for biological activities including anti-inflammatory and anti-oxidative potential. However little is known about anti-cancer property. In this study, we investigated the anti-prostate cancer activity of mushrooms. For that, eight kinds ofmushrooms such as, T. matsutake, S. crispa, G. lucidum-US, G. lucidum-AS, C. cardinalis-BR, G. frondosa, P. linteus, U.esculenta were extracted with hot water. Among them, three kinds of mushrooms including T. matsutake, G. lucidum-US andC. militaris-BR extracts inhibited prostate specific antigen (PSA) expression in prostate cancer cell, LNCaP. These resultsdemonstrate that some of mushrooms inhibited PSA expression suggesting that the mushrooms might be a candidate for thetreatment of prostate cancer.

서 론
 재료 및 방법
  버섯시료 추출 방법
  세포 배양
  RNA isolation
  RT-PCR (Reverse Transcription-Polymerase ChainReaction)
  정량적 역전사 반응(Real-time quantitative polymerasechain reaction, qPCR)
  PCR정량 분석
  통계처리
 결과 및 고찰
  전립선암세포(LNCaP)에서 8종 버섯류 열수 추출물의PSA mRNA 발현 억제효과
  전립선암세포(LNCaP)에서 참송이버섯, 편각영지버섯및 현미동충하초버섯 열수 추출물의 PSA mRNA 발현 억제효과
 적 요
 감사의 글
 References

• 김은경(건국대학교 식품생명과학부) | Eun-Kyung Kim
• 당옥교(건국대학교 식품생명과학부) | Yujiao Tang
• 최희리(건국대학교 스포츠과학부) | Heeri Choi
• 최은주(건국대학교 스포츠과학부) | Eun-Ju Choi Corresponding author