Background : Dibenzocyclooctadiene lignans are secondary metabolites present abundantly in the fruits belonging to the genus Schisandra. According to previous studies, Schisandra lignans exhibit anti-inflammatory, anti-cancer and anti-diabetic properties, as well as an inhibitory effect on platelet aggregation. Therefore, establishing the Korean “Omija” (Schisandra chinensis) as a lignanrich source, in addition to identifying and quantifying the lignans, is extremely valuable.
Methods and Results : Dibenzocyclooctadiene lignans were analyzed with liquid chromatography using diode array detection/ mass spectrometry, from methanol extracts subsequently identified by a constructed chemical library of 50 lignans. A total of 27 components of lignan including gomisin S were identified, of which schisandrin, gomisin A, gomisin N, deoxyschisandrin, γ- schisandrin, and schisandrin C were identified as the major components in the Korean Omija, Schisandra chinensis. These compounds were divided into two groups, S-biphenyl and R-biphenyl based on the configurations of the stereoisomers structures with contents of 661.7 and 1350.1㎎ per 100 g dry weight, respectively. The total lignan content averaged 2011.4㎎ per 100 g dry weight, of which schisandrin and gomisin N comprised the majority (771.8 and 420.5㎎ per 100 g dry weight respectively).
Conclusions : Lignans which are present in high quantities in the ripe fruit of Schisandra chinensis are important functional compounds that play a major role in the prevention and treatment of human diseases.

서 언
 재료 및 방법
  1. 공시 재료
  2. 기기 및 시약
  3. 시료 전처리
  4. 오미자 열매로부터 리그난 화합물 라이브러리 제작
  5. HPLC-DAD-ESI/MS를 이용한 개별 리그난 동정 및 정량분석 
 결과 및 고찰
 감사의 글
 REFERENCES

• 김헌웅(농촌진흥청 국립농업과학원) | Heon Woong Kim
• 신재형(농촌진흥청 국립농업과학원) | Jae Hyeong Shin
• 이민기(농촌진흥청 국립농업과학원) | Min Ki Lee
• 장가희(농촌진흥청 국립농업과학원) | Ga Hee Jang
• 이성현(농촌진흥청 국립농업과학원) | Sung Hyeon Lee
• 장환희(농촌진흥청 국립농업과학원) | Hwan Hee Jang
• 정석태(농촌진흥청 국립농업과학원) | Seok Tae Jeong
• 김정봉(농촌진흥청 국립농업과학원) | Jung Bong Kim Corresponding author