The effects of extracts from Lentinula edodes (L. edodes) and Aquilariae agallocha (A. agallocha) on the DNA damage response in ultraviolet A (UVA)-exposed HaCaT cells and on the allergic contact dermatitis caused by 2,4-dinitro-chlorobezene (DNCB) were investigated. When UVA-exposed cells were incubated for 24 hours in medium containing L. edodes or A. agallocha extract, the level of 8-OHdG and CPD decreased in a concentration-dependent manner. The combined treatment with both extracts potentiated the decrease in UVA-induced 8-OHdG and CPD levels as compared with those following treatment with a single extract. In addition, the two extracts showed preventive effects against the UVA-induced reduction in collagen levels. Furthermore, the blood levels of IgE, IL-6, and histamine decreased more significantly upon combined treatment with L. edodes and A. agallocha extracts as compared with those following treatment with single extracts in DNCB-induced allergic contact dermatitis in the ICR mouse. The results of the present study suggest that the components with in the extracts of L. edodes and A. agallocha can help to prevent of UVA-induced genomic instability via a decrease in DNA damage, and to decrease the DNCB-induced allergic dermatitis via modulation of relevant proteins including IgE and IL-6. Further study is needed to clarify the purified components related to the preventative effects of the two extracts against UVA- or DNCB-induced genomic damage.

서론
재료 및 방법
결과 및 고찰
요약 및 결론
감사의 글
References

• 김민섭(원광대학교 생명과학부 기초자연과학연구소) | Min Seob Kim
• 황현익(원광대학교 생명과학부 기초자연과학연구소) | Hyun Ik Hwang
• 이유리(원광대학교 생명과학부 기초자연과학연구소) | Yu Ri Lee
• 김호원(원광바이오 시스템) | Ho Won Kim
• 박종군(원광대학교 생명과학부 기초자연과학연구소) | Jong Kun Park Corresponding Author