This study presents the possibility of control of nano-fluidics in the bio-inspired nano-sized ion channel using a field effect transistor (FET) structure. We analyzed effects from main dominant factors to control the ion flow in nano-sized channel such as electro-osmosis, Diffusion effect, Coulomb force between ions and pressure force. Additionally, we suggest a strategy to control the ion flow accurately at the specific position in the nano channel by handling the viscosity, ion molecular density, pressure, gate and trans-cis voltages of FET structure.