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HPLC analysis of ferulic acid and its pharmacokinetics after intravenous bolus administration in rats KCI 등재

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충북대학교 동물의학연구소 (Research Institute of Veterinary Medicine, Chungbuk National University)
초록

We investigated the pharmacokinetics of ferulic acid, a potential antioxidant agent, after intravenous (i.v.) bolus administration in rats. To analyze ferulic acid levels in the plasma, bile, urine and tissue samples, we developed an HPLC-based method which was validated for a pharmacokinetic study by suitable criteria. After i.v. bolus administration of ferulic acid, it rapidly disappeared from blood circulation within 15 min. The mean plasma half-lives at α phase (t1/2α) when administered at doses of 2 and 10 mg/ kg were 1.10 and 1.39 min, respectively. The values of t1/2β at the corresponding doses increased 40% (from 5.02 to 7.01 min) with increasing doses. The total body clearance (CLt) values significantly decreased as the ferulic acid dose increased. On the other hand, steady-state volume of distribution (Vdss) values did not show the significant difference with the increase in dose. Of the various tissues, ferulic acid mainly distributed to the liver and kidney after i.v. bolus administration. The ferulic acid concentrations in various tissues at 2 hr after i.v. bolus administration were below 1.0 μg/g tissue. Ferulic acid was excreted in the bile and urine after i.v. bolus administration at the dose of 10 mg/kg. The cumulative amount of ferulic acid in the bile 2 hr after dosage was comparable with the amount excreted in the urine after 72 hr, indicating that i.v. administered ferulic acid was mainly excreted in the both bile and urine. In conclusion, ferulic acid was rapidly cleared from the circulating blood and transferred to tissues such as the liver and kidney after i.v. bolus administration. Moreover, the majority of ferulic acid appears to be excreted in the bile and urine after i.v. bolus administration.

목차
Introduction
Materials and Methods
Results
Discussion
Acknowledgements
ORCID
References
저자
  • Dae Hwan Shin(College of Pharmacy, Chungbuk National University)
  • Han Jun Cho(College of Pharmacy, Chungbuk National University)
  • Seong Hyeok Park(College of Pharmacy, Chungbuk National University)
  • Sung Woo Jeong(College of Pharmacy, Chungbuk National University)
  • Chun-Woong Park(College of Pharmacy, Chungbuk National University)
  • Kun Han(College of Pharmacy, Chungbuk National University)
  • Youn Bok Chung(College of Pharmacy, Chungbuk National University) Corresponding author