The aim of the present study was to develop an animal model for evaluation of temporomandibular (TMJ) nociception under TMJ inflammation. We also investigated the participation of IL-1β in inflammation-induced TMJ nociception. Experiments were carried out using male Sprague-Dawley rats. Intra-articular injection of 3% formalin was administered to evaluate hyperalgesia 3 days after CFA injection. Intra-articular injection of 3% formalin did not produce nociceptive behavior in normal rats. Although intra-articular injection of 3 doses of CFA produced TMJ inflammation, only 1:3 diluted CFA produced hyperalgesia when formalin was injected intra-articularly 3 days after CFA injection. Co-administration of IL-1 receptor inhibitor with formalin into the TMJ cavity 3 days after CFA injection was performed. Co-administration of IL-1 receptor inhibitor significantly inhibited formalin-induced hyperalgesia in rats with CFA-induced TMJ inflammation. These results suggested that intra-articular injection of formalin produced hyperalgesia under chronic TMJ inflammation. Moreover, IL-1β plays an important role in TMJ hyperalgesia under chronic inflammation and blockade of IL-1β is a potential therapeutic target for inflammatory TMJ pain.

서 론
 재료 및 방법
  실험동물
  측두하악관절에서 만성 염증발생
  Formalin에 의해 유도되는 통증반응의 평가
  측두하악관절강 내로 주입한 IL-1 수용기 차단제 효과
  통계분석
 실험 결과
 고 찰
 References

• Jin-Sook Ju(Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea)
• Seung-Ho Choi(Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea)
• Hye-Jin Kim(Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea)
• Jo-Young Son(Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea)
• Dong-Kuk Ahn(Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea) Corresponding Author