Control of the vector mosquitoes is critical for implementation of patient’s decrease. Vector mosquito control has been mainly carried out using pesticides in Republic of Korea (ROK), which has developed the resistance against selected insecticides. Voltage-gated sodium channel (VGSC) and Acethylcholine esterase (AchE) are the target of several classes of insecticides. Genetic mutations of VGSC and AchE have been documented to confer resistances to pyrethroids and organophosphates in mosquitoes, respectively. In our studies, the insecticidal resistable level of An. sinensis from four malaria risk areas near Demilitarized Zone (DMZ) was measured. The partial sequence of An. sinensis voltage gated sodium channel (VGSC) IIS6 domain for Kdr gene and ace1 gene for AchE was sequenced. An. sinensis from two areas demonstrated significantly higher resistance to pyrethroids and mutation rates of Kdr gene were comparatively higher. In all tested areas An. sinensis showed high insecticidal resistance to organophosphates and > 70% of mutation rates of ace1 gene ware higher. Understanding the mechanisms of insecticide resistance among vector mosquitoes populations is very important to efficient and effective vector control.

• Se Jin Jeong(Division of Medical Entomology, Center for Immunology and Pathology, NRIH, KCDC)
• Chang won Jang(Division of Medical Entomology, Center for Immunology and Pathology, NRIH, KCDC)
• Jin Hwan Jeon(Division of Medical Entomology, Center for Immunology and Pathology, NRIH, KCDC)
• Gi-Hun Kim(Division of Medical Entomology, Center for Immunology and Pathology, NRIH, KCDC)
• E-Hyun Shin(Division of Medical Entomology, Center for Immunology and Pathology, NRIH, KCDC)
• Young-Ran Ju(Division of Medical Entomology, Center for Immunology and Pathology, NRIH, KCDC)
• Kyu-Sik Chang(Division of Medical Entomology, Center for Immunology and Pathology, NRIH, KCDC)