Swine industry has been focusing selection of excellent breeding pigs for post decades. This result is created to superior breeding sows with larger litter size, which are leads to low birth weight piglets (LBW) because of intrauterine growth retardation. The LBW on development of pigs have well known to postpone growth performance and to disrupt body metabolisms than normal birth weight piglets (NBW). However, effect of LBW on reproductive functions is very not documented. Therefore, this study was conducted to identify effect of birth weight on reproductive function in the LBW compared with normal birth weight piglets (NBW) by RNA sequencing and pathway studio. The experimental animals utilized 3d old LBW (0.96±95.07 kg, n=4) and NBW (1.69±83.39 kg, n=4). The differentially expressed genes were approximately 800 genes above 2 fold. The genes were related to steroid hormone synthesis, estrogen receptors signaling and growth and proliferation of cells. These results may be suggested to affect development of reproductive organ. However, our data are restricted using young experimental animals.

• Yong-Dae Jeong(National Institute of Animal Science, Rural Development Adminstration)
• Eun Seok Cho(National Institute of Animal Science, Rural Development Adminstration)
• Jae-Seok Woo(National Institute of Animal Science, Rural Development Adminstration)
• Soo Jin Sa(National Institute of Animal Science, Rural Development Adminstration)