방사선에 의해서 유도된 간 손상에 대한 백삼과 발효인삼추출물의 보호효과를 비교 연구하였다. ICR계 생쥐에게 코발트-60 감마선의 5Gy조사 7일 전부터 백삼과 발효인삼추출물(150㎎/㎏/day)을 각각 투여하였 다. 대조군은 생리적 식염수를 투여하고 방사선조사군은 생리적 식염수를 투여하면서 5Gy를 조사하였다. 그리고 각각의 실험군에서 간조직의 H2O2, catalase, MDA를 측정하였다. 그 결과 방사선조사군과 보다 백 삼과 발효인삼추출물 투여군에서 catalase함량이 유의성 있게 증가하여 간의 보호효과가 있었으며 H2O2와 MDA함량도 유의성 있게 감소하였다. 백삼과 발효인삼이 간 조직에 대한 방사선조사로 부터 매우 우수한 방호제라고 할 수가 있다.
The effects of White Ginseng and Fermented Ginseng on liver damage induced by 60Co r-ray irradiation were investigated. To one group of ICR male mice were given in White Ginseng(150 ㎎/㎏/day for 7days, orally) before 5Gy(1.01Gy/min) dose of 60Co r-ray irradiation. To another group were given in Fermented Ginseng (150 ㎎/㎏/day for 7days, orally)before 5Gy(1.01Gy/min)dose of 60Co r-ray irradiation was investigated. Radiation irradiation group were given with saline(0.1 ml) and 5Gy. Contrast group were given with saline(0.1 ml). The levels of H2O2, catalase and MDA in liver tissue were measured. In Fermented Ginseng (FG+Rad) group and white Ginseng(WG+Rad) group than irradiation group(Rad), the catalase level were significantly increased, and the catalase levels were appeaWhite at radiation protection. It was significantly decreased to MDA and H2O2 level to Fermented Ginseng (FG+Rad) group and white Ginseng(WG+Rad) group than irradiation group(Rad). Therefore, Fermented Ginseng and white Ginseng were very excellent protector on radiation of liver in mice.