Reactive oxygen species (ROS) induces oxidation against various biomolecules including fatty acids. Calcium-independent cellular phospholipase A2 (iPLA2) has been known to function maintenance of fatty acids in phospholipids in mammals. An insect iPLA2 (Pi-iPLA2) was predicted from transciptomes of the Indianmeal moth, Plodia interpunctella. It was expressed in all developmental stages from egg to adult. RNA interference (RNAi) against Pi-iPLA2 was performed with specific double-stranded RNA (dsRNA) with more than 70% efficiency in reduction of its expression. Under this RNAi condition, P. interpuctella exhibited developmental retardation with significant accumulation of lipid peroxidation measured by the amount of melondialdehyde

• 한경덕(고려대학교 생명공학부)
• 김철영(안동대학교 식물의학과)
• 수닐쿠마르(안동대학교 식물의학과)
• 김욱(고려대학교 생명공학부)
• 김용균(안동대학교 식물의학과)