As an important aspect of vulnerability ,economic vulnerability is a research hot issue in vulnerability and Tourism sustainability research field. On the basis of defining vulnerability, the paper combines vulnerability with the tourism economic system. Taking the Yellow River delta efficient ecological economic zone as an example, the paper establishes an assessment model of tourism economic system vulnerability, and evaluates the tourism economic system vulnerability using the entropy method and the comprehensive evaluation method. Using obstacle degree analyze the main obstacle factors of cities in the paper . The evaluation result is that the Yellow River delta efficient ecological economic zone has a vulnerable tourism economic system, which is almost in line with the actual situation.