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인디루빈 유도체에 의한 구강암 KB 세포의 apoptosis 유도 KCI 등재

Indirunin Derivatives Induces Apoptosis in Oral Squamous Carcinoma KB Cells

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대한구강악안면병리학회지 (The Korean Journal of Oral and Maxillofacial Pathology)
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

Indirubin is the active ingredient 0 1' a traditional Chinese herbal medicine, Danggui Longhui Wan, used for the t reatment of chronic myelocytic leu kelma The author reports that novel indirubin derivative, 5'-nitro-indirubinox ime (5'-NIO) , has potent a nti -proliferative activity on human o1'al cancer cells , Treatment of KB cells with 5’ NIO s howed a s t rong cell growth inhibit ion during indicated time point , A typical apoptosis pattern was obtained with DNA fragmenta tion and i mmunofl uorescence analysis of annelxn-v-f!ous Western blot data revealed that p53 and p21CIP1/Waf- l level increased strongJy upon 5'-NIO treatment , The a uthor next tested whether 5'-NIO could activate apoptos is related proteins s uch as caspase-3/-7/-9, [n cells exposed to 5‘-NIO, activation of caspase-3 and -7 was observed, Interesti ngly‘ caspase-9 and cytochrome c cou ld s li ghtly activate in response to 5’-NIO. These results indicate that 5’-NIO strongly induces oral cancer cells apoptosis via a Mi tochondria-mediated cas pase cascade pathway, These observations together s uggest that 5’ NTO may have a possible therapeutic potentia[ to oral cancer

저자
  • 전영찬(조선대학교 치과대학 병리학교실) | Young Chan Chon
  • 황덕호(조선대학교 치과대학 병리학교실) | Deok Ho Hwang
  • 김규식(조선대학교 치과대학 병리학교실) | Gyu Slk Kim
  • 김수아(동국대학교 한의과대학 생화확교실) | SOO A Kim
  • 안상건(조선대학교 치과대학 병리학교실) | Sang Gun Ahn Correspondence
  • 윤정훈(조선대학교 치과대학 병리학교실) | Jung Hoon Yoon Correspondence