Several tumor animal models have been provided as a tool for developing cancer therapy. Here, we developed rapid, easy-to use, and cost-effective new rat animal model for invasion and metastasis of cancer using genetically k-ras-induced rat kidney cells(RK3E-ras). We observed tumor as early as 3 days after injection of RK3E-ras cells in subcutaneous of Sprague-Dawley rats. Tumor size and volume were increased exponentially for 2 weeks. The tail vein injected rats obtained the lethal infiltration in the lung within 2 weeks. This tumor animal model has great potential for studying cancer processes and short-term screening of variable cancer therapy strategy.

• 김현우(조선대학교 치과대학 구강병리학교실, BK 21) | Hyun-Woo Kim
• 김수아(조선대학교 치과대학 구강병리학교실, BK 21) | Soo A Kim
• 안상건(조선대학교 치과대학 구강병리학교실, BK 21) | Sang Gun Ahn
• 윤정훈(조선대학교 치과대학 구강병리학교실, BK 21) | Jung Hoon Yoon Correspondence