A novel indil‘ubin analog‘ 5’ nitro-indirubinoxime(Ol1) inhibits cell proliferation and induces apoptosis again st variolls hllman cancer cell s. ln this stlldy, we performed the microarray analysis to identify genes diffel'enti ally expressed in the KB oral sqllamollS carcinoma cells after treatment with 011 Of the 10‘ 800 genes a nalyzed , 1700 genes(15.7%) showed di fferent expression level in the 011-treated cells with respect to untreated control cel1s Arnong those‘ 263 genes(15, 5%) were down -reg띠 ated and 220 genes(12, 9%) were IIp-regulated more than 2-fold, Functionally related gene clllsters inclllde genes associated with signal transdllction(18, 1%) , especially genes re lated with a poptosis(3, 5%) and cell cycle reglllation(5. 8%) . Our application of microarray ar뻐ysis on 01l-treated 01'외 cancer cells al lows the identifi cati on of candidate genes for providing novel insights into the 011-mediated anti -tllmor actl Vl ty ,

• Soo A Kim(Department of Pathology, BK 21 Project, Chosun University College of Dentistry)
• Eun Soon Oh(Department of Pathology, BK 21 Project, Chosun University College of Dentistry)
• Seong Min Kwon(Department of Pathology, BK 21 Project, Chosun University College of Dentistry)
• Young Ho Woo(Department of Pathology, BK 21 Project, Chosun University College of Dentistry)
• Sang Gun Ahn(Department of Pathology, BK 21 Project, Chosun University College of Dentistry)
• Jung Hoon Yoon(Department of Pathology, BK 21 Project, Chosun University College of Dentistry)