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Insulin-like growth factor system : 흰쥐 턱밑샘에서의 증령적 mRNA 정량 KCI 등재

Insulin-like Growth Factor System : Age-related Quantitation of mRNA in the Rat Submandibular Gland

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대한구강악안면병리학회지 (The Korean Journal of Oral and Maxillofacial Pathology)
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

Agi ng adversely affects the structure and function of the saliva ry gla nd and leads to ma rked insulin resis t ance that correlates with red uced ins ulin s ignal t ra nsduction, lnsulin-like g rowth factors are k.nown to be regulator involved in embryonic a nd postnatal development with sequences 62% identical t o that of proins ulin , To determine whether i n suli n- like growth facto l' - l, -2, - 1 receptor a l'e involved in the changes in rat salival'y gland by aging, we a na lyzecl the qua nti tation of 19f - 1, -2, - 1 rece ptor mRNA in l'at salivary glancl between 2 weeks and 26 months after bir th using the competiti ve reverse t ra nscriptase-polymerase chain reaction(RT-PCR) methocl Between 2 weeks ancl 2 months age, sharp falls in the qua nt ities of Igf-2 mRNA were observed, W11ereas Igf- 1 receptor mRNA rose by aging, but not sig nifïcantly, The quanti t ies of 19f- l kept by aging, These change seem to be involvecl a role fol' the Igf-2 in sali va ry c1evelopment a ncl earl y growth is incli ca ted, Thus, t he dras tic changes in the qua ntities of Igf-2 mRNA in the ra t sali va ry gla nd by aging seem to be in volved in the development, early growth and homeostasis of sali vary gla nd,

저자
  • 류숙경(전북대학교 수의과대학 병리학교실 및 생체안전성연구소) | Sook Kyoung Ryou
  • 임채웅(전북대학교 수의과대학 병리학교실 및 생체안전성연구소) | Chae Woong Lim
  • 김효분(전북대학교 치과대학 구강병리학교실 및 구강생체과학연구소) | Hyo Bun Kim
  • 손현진(전북대학교 치과대학 구강병리학교실 및 구강생체과학연구소) | Hyun Jin Son
  • 조남표(전북대학교 치과대학 구강병리학교실 및 구강생체과학연구소) | Nam Pyo Cho