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Implantation Rate Increased by Uterus Endometrial Injury in sDM Rat

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한국동물생명공학회(구 한국수정란이식학회) (Journal of Animal Reproduction & Biotechnology)
초록

Embryo transfer is one of the important process of assisted reproductive technology (ART) and that is associated with uterus endometrial receptivity. Recently, mouse endometrial stimulation by artificial injury had shown the favorable effect on conception. In this experiment, we used uterus stimulation method that injury the endometrium to increase implantation rate for spontaneous Diabetes Mellitus (sDM) rat. Rats are divided into several groups involved a control group. We performed the surgical method to Experimental group bilaterally or unilaterally After that, we investigated morphological change and calculated implanted embryos respective sides of the uterus. The number of implanted embryo in the experimental group was significantly higher and there were lots of morphological changes including glands and endometrial cells that support implantation. Our results showed that rat uterus endometrial injury in ART help enhancing implantation rate.

저자
  • Hoseung Kwak(Department of Bio-Nano Science, College of BioNano Technology, Gachon University)
  • Donghun Kang(Department of Bio-Nano Science, College of BioNano Technology, Gachon University)
  • Jihye Jang(Department of Life Sciences, College of BioNano Technology, Gachon University)
  • Eunjoo Lee(Department of Life Sciences, College of BioNano Technology, Gachon University)
  • Daeyoung Kim(Department of Life Sciences, College of BioNano Technology, Gachon University)