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Hair Growth Effect of Ethanol Extract from Houttuynia cordata Thunb. Whole Plant and Calendula officinalis L. Flower

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  • URLhttps://db.koreascholar.com/Article/Detail/326193
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한국약용작물학회 (The Korean Society of Medicinal Crop Science)
초록

Background : Recently, hair loss, which has been regarded as a mere means of middle-aged men due to stress and environmental pollution. The market for hair loss in Korea is about four trillion won and it is growing continuously. It is mainly made by mixing natural extracts such as medicinal plant. The purpose of this study was to investigate the effects of ethanol extracts of Houttuynia cordata Thunb. whole plant and Calendula officinalis L. flower extracts on the growth of fibroblasts, dermal papilla cells and lipid precursors, I want to try to make a materialization. Methods and Results : The cytotoxicity of each sample extracts treated with 50%, 100%, and 500 μg to fibroblasts, cell-viability were 107.3%, 109.6%, and 128.2%, respectively. The cytotoxicity of each sample to the dermal papilla cells was not observed. And the lipid differentiation of the lipogenic precursor cells which regulates the hairegeneration by secretion of the platelet derived growth factor. The 70% ethanol extracts of H. cordata whole plant and C. officinalis flower were showed promotes the hair growth activity. The lipolysis rate was significantly increased with increasing treatment concentration Conclusion : As a result of this study, in-vitro hair growth activity of herbal medicines for hair treatment material development was not shown to be toxic to each cell. And 70% ethanol extract of H. cordata whole plant stimulated lipid precursor cells inducing differentiation. As a result, the 70% ethanol extracts of H. cordata whole plant and C. officinalis flower have potential to developing hair-related product.

저자
  • Seong Woo Jin(Jangheung County Mushroom Research Institute) | 진성우
  • Kyung Je Kim(Jangheung County Mushroom Research Institute) | 김경제
  • Young Woo Koh(Jangheung County Mushroom Research Institute) | 고영우
  • Seung Bin Im(Jangheung County Mushroom Research Institute) | 임승빈
  • Sang Wook Jeong(Jangheung County Mushroom Research Institute) | 정상욱
  • Kwang Sang Kim(Hisol Co.) | 김광상
  • Min Sook Kim(Hisol Co.) | 김민숙
  • Byung Jo Yu(Korea Institute of Industrial Technology) | 유병조
  • Ji Yeon Jang(Korea Institute of Industrial Technology) | 장지연
  • Kyungsun Seo(Jangheung County Mushroom Research Institute) | 서경순 Corresponding author