Background : This study was conducted to investigate the antioxidant activities and anticancer effect in 80% ethanol extract from foxtail millet (Setaria italica) and proso millet (Panicum miliaceum) and sorghum (Sorghum bicolor) varieties. Methods and Results : These extracts were evaluated for contents of total polyphenol and antioxidant activities using DPPH and ABTS radical scavenging activities. In concentration of 1000 ㎍/㎖, total polyphenol contents of foxtail millet, proso millet and sorghum were 7.68 - 12.74 ㎍․GAE/㎖, 13.01 - 14.79 ㎍․GAE/㎖ and 48.24 - 62.33 ㎍․GAE/㎖, respectively. Sorghum extracts showed strong radical scavenging activity comparable to well-known antioxidant, trolox. Anticancer effect was evaluated for MTT assay using AGS human gastric cancer cells. All extracts decreased growth of AGS cancer cells. Foxtail millet extracts were decreased about 40% of cell viability in all concentrations. Sorghum extracts were decreased cell viability, concentration dependent manner. Especially, Donganme extract (one of the sorghum variety) was the highest anti cancer effect under AGS cancer cells. Conclusion : Based on these results, millet and sorghum has potential health promoting bioactive compounds as functional food.

• Ji Myung Choi(Department of Southern Area Crop Science, National Institute of Crop Science, RDA) | 최지명 Corresponding author
• Jee Yeon Ko(Department of Southern Area Crop Science, National Institute of Crop Science, RDA) | 고지연
• Seok Bo Song(Department of Southern Area Crop Science, National Institute of Crop Science, RDA) | 송석보
• Myeong Eun Choe(Department of Southern Area Crop Science, National Institute of Crop Science, RDA) | 최명은
• Chang Hwan Park(Department of Southern Area Crop Science, National Institute of Crop Science, RDA) | 박장환
• Do Yeon Kwak(Department of Southern Area Crop Science, National Institute of Crop Science, RDA) | 곽도연