Background : Cordyceps militaris is a non-toxic, medicinal mushroom, which is known to possess anti-inflammatory and immunomodulating activities. And also, Glycyrrhiza uralensis is widely used as a crude drug in oriental medicine. However, the effects and mechanism of action of C. militaris and G. uralensis on Herpes simplex virsu (HSV), which is a serious skin disease. This study aimed to evaluate the effect of C. militaris and G. uralensis on Herpes simplex virus. Methods and Results : The results showed that the extracts and major compounds C. militaris and G. uralensis increased the TNF-α product on RAW 264.7. And also, these extracts and major compounds inhibited TNF-α product in RAW 264.7 induced by LPS. Querceitn, which was identified from G. uralensis, was showed Anti-virrus effect of Herpes simplex virus (HSV). Conclusion : Taken together, these results indicate that the anti-stomach cancer effect of C. militaris and G. uralensis in xenograft model implantated Epstein-Barr virus positive-stomach cancer cell line.

• Yu Su Shin(National Institute of Horticultural and Herbal Science, RDA) | 신유수 Corresponding author
• Chan Hum Park(National Institute of Horticultural and Herbal Science, RDA) | 박찬흠
• Ji Hye Yoon(National Institute of Horticultural and Herbal Science, RDA) | 윤지혜
• Sang won Lee(National Institute of Horticultural and Herbal Science, RDA) | 이상원
• Hyo Sun Cho(Duksung Women’s University) | 조효선
• Hyo Jung Kang(Kyungbuk National University) | 강효정