Background: Hyperglycemia, or high blood sugar, is a serious problem in diabetes. Hyperglycemia induces the generation of free radicals which disrupts insulin signaling and result in insulin resistance. The aim of this study was to evaluate the antioxidant and hypoglycemic potentials of LBO-1 mixture. Methods and Results: To evaluate antioxidant effect of LBO-1 mixture, DPPH, ABTS and reducing power were performed. LBO-1 mixture scavenged DPPH free radicals and ABTS radicals in a dose-dependent manner. The total phenolic contents of LBO-1 mixture was determined by a regression equation using a calibration curve by gallic acid equivalents. The obtained total phenolic contents were 65.90 ± 0.52 ㎎/g. Phenolic components of plant extracts that can scavenge free radicals. In addition, we evaluated effects of LBO-1 mixture on glucose production in high glucose-induced HepG2 hepatocytes. LBO-1 mixture decreased glucose levels in cultured medium and it down regulated Phosphoenolpyruvate carboxykinase (PEPCK) levels which is an enzyme used in the metabolic pathway of gluconeogenesis. Conclusion: These results indicate that the LBO-1 mixture can be used as hypoglycemic agent.

• Taek Hwan Lee(Department of Bio-Medical and Health Science, Konkuk University AG-Health Research Center) | 이택환
• Seong Min Hong(Department of Bio-Medical and Health Science, Konkuk University) | 홍성민
• In Sook Kim(Department of Bio-Medical and Health Science, Konkuk University) | 김인숙
• Young Min Lee(Department of Bio-Medical and Health Science, Konkuk University) | 이영민
• Ghosh Mithun(Department of Bio-Medical and Health Science, Konkuk University) | 미툰 고쉬
• Beong Ou Lim(Department of Bio-Medical and Health Science, Konkuk University) | 임병우 Corresponding author