Nanoemulsions are actively used in several applications for pharmaceutical, cosmetic and chemical industries. In this study, we propose the use of microfluidizer known as high pressure homogenizer to prepare lipid nanoemulsion as a potent cosmetic delivery carrier. The lipid nanoemulsions were prepared by O/W emulsion with hydrogenated lecithin and different type of oils. Effects of oil type on the stability of the lipid nanoemulsion were investigated with Dynamic Light Scattering (DLS) and Zeta-potential. Arbutin was used as model drug for transdermal administration through hairless mouse skin. Transdermal arbutin delivery using the lipid nanoemulsions was studied with HPLC method.

• Seung-Jun Lee(Department of Chemical & Biomolecular Eng., KAIST, 291, Daejeon, 34141, Republic of Korea)
• Sa Ra Han(Department of Chemical Engineering, Soongsil University, Seoul, 06978, Republic of Korea)
• Jae Hyun Jeong(Department of Chemical Engineering, Soongsil University, Seoul, 06978, Republic of Korea) Corresponding author
• Jong-Duk Kim(Department of Chemical & Biomolecular Eng., KAIST, 291, Daejeon, 34141, Republic of Korea)