V-Coupling is commonly used as a mechanical fastener to connect the turbine housing and the bearing housing in a turbocharger assembly. The back plate between the turbine housing and bearing housing would be compressed by tightening torque of the coupling bolt in order to protect the gas leakage at a turbocharger’s operation. This paper presents the numerical and experimental method for the prediction of the mechanical behavior and sealing performance of the coupling system. The test was conducted to verify the finite element model by measuring the circumferential and axial direction strains of V-coupling under turbocharger’s assembly load. Finite element analysis was carried out to obtain the mechanical strains and contact pressures of the coupling. It can be seen that the analysis results are in good agreement with the measured strains from the coupling’s assembly load. And, the pressure distribution of the back plate also presented to identify the sealing performance of the turbocharger’s coupling system.