The object of this study was to obtain single oral dose toxicity of Arisaema Rhizome (Arisaema amurense f. serratum (Nakai) Kitag) aqueous extracts. Arisaema Rhizome (Chunnamsong in Korean) is one of the most important folk remedy plants used in Asia. In the study, a 28-day rat oral gavage study has been conducted with the extracts from Arisaema Rhizome at dose of 1,250, 2,500 and 5,000 ㎎/㎏/day. The following endpoints were evaluated: clinical observations, body weight, gross and microscopic pathology, clinical chemistry, and hematology. Based on the analysis of these endpoints, it was estimated that NOEL (no observed effect level) for male rats and NOAEL (no observed adverse effect level) for female rats are 5000 ㎎/㎏/day of the water-extracts from Arisaema Rhizome.

• 김민경(한국한의학연구원 한의기반연구부) | Min-Kyeoung Kim (KM Fundamental Research Division, Korea Institute of Oriental Medicine)
• 이지선(대구카톨릭대학교 GLP센터) | Ji Sun Lee (GLP Center, Catholic University of Daegu)
• 박영철(대구카톨릭대학교 GLP센터) | Yeong Chul Park (GLP Center, Catholic University of Daegu)
• 최선미(한국한의학연구원 한의기반연구부) | Sun Mi Choi (KM Fundamental Research Division, Korea Institute of Oriental Medicine)
• 이상훈(한국한의학연구원 한의기반연구부) Corresponding author