Here we report the protective activity of cultured Acer tegmentosum cell extract against liver damage in rat intentionally instigated by D-galactosamine. Local fat degeneration and infiltration of inflammatory cells were significantly decreased in cultured A. tegmentosum cell extract administered rat. In addition, acutely increased AST, ALT, LDH, ALP activities and lipid peroxidation and lipid content by liver damage were recovered in experimental rat administrated with A. tegmentosum extract. These results showed that cultured A. tegmentosum cell extract has a role in blood enzyme activation and lipid content restoration within damaged rat liver tissues. Moreover expression rate of TNF-α which accelerates inflammation and induces tissue damage and necrosis was significantly decreased. Also activities of antioxidant enzymes were more effectively upregulated comparing to those of the control group induced hepatotoxicity. All data that cultured A. tegmentosum cell extract has a preventive role against liver damages such as inflammation, tissue necrosis in rats by improving activities of blood enzymes, antioxidant enzymes and modulating expression of inflammation factor, suggest that cultured Acer tegmentosum cell extract is an effective medicinal resource for restoration of hepatotoxicity.

• 서을원(안동대학교 자연과학대학 생명과학과, 안동대학교 해양바이오산업연구소) | Eul Won Seo (Department of Biological Science, Andong National University, Institute of Marine Biotechnology, Andong National University) Corresponding author
• 임재환(안동대학교 자연과학대학 생명과학과) | Jae Hwan Lim (Department of Biological Science, Andong National University)
• 김창헌(삼양제넥스 생명공학연구소) | Chang Heon Kim (Biotechnology R&D Center, Samyang Genex Corporation)
• 김진아(삼양제넥스 생명공학연구소) | Jin Ah Kim (Biotechnology R&D Center, Samyang Genex Corporation)
• 박영미(안동대학교 자연과학대학 생명과학과) | Young Mi Park (Department of Biological Science, Andong National University)