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차전초(Plantago asiatica L.)의 항톡소포자충증 효과 KCI 등재

Anti-Toxoplasmosis Effect of the Herbal Extracts Plantago asiatica L.

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한국자원식물학회지 (Korean journal of plant resources)
한국자원식물학회 (The Plant Resources Society Of Korea)
초록

Toxoplasmosis is an important cause of foodborne, inflammatory illnesses, as well as congenital abnormalities. Currently available therapies are ineffective for persistent chronic disease and congenital toxoplasmosis or have severe side effects which may result in life-threatening complications. There is an urgent need for safe and effective therapies to eliminate or treat this cosmopolitan infectious disease. The aim of this study was to investigate the in vitro anti-Toxoplasma activities of Plantago asiatica L., one of the herbal extracts, using tachyzoit of T. gondii RH strain infected HeLa cells. As the results, the selectivity of Plantago asiatica L. extract was 4.5, which was higher than Sulfadiazine selectivity (0.4). Also, we perfomed the cell proliferation inhibition test and the morphological study to evaluate the anti-T. gondii activity of Plantago asiatica L. extract with HeLa cells. As the results, the inhibition rate of the Plantago asiatica L. extract was high inhibition rate. This indicates that the Plantago asiatica L. extract may be used for new anti-T. gondii agent.

저자
  • 홍선화(원광대학교 동물자원개발연구센터) | Sunhwa Hong (Center for Animal Resources Development, Wonkwang University)
  • 김옥진(원광대학교 동물자원개발연구센터, 원광대학교 농학과 대학원) | Okjin Kim (Center for Animal Resources Development, Wonkwang University, Department of Agronomy, Wonkwang University) Corresponding author