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식방풍잎(Peucedanum japonicum Thunberg L.)의 물추출물이 3T3-L1 세포와 고지방식이로 유도된 마우스에서 항비만 효과 KCI 등재

Anti-obesity Effects of Peucedanum japonicum Thunberg L. on 3T3-L1 Cells and High-fat Diet-induced Obese Mice

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한국자원식물학회지 (Korean journal of plant resources)
한국자원식물학회 (The Plant Resources Society Of Korea)
초록

Obesity is a pro-inflammatory state that contributes to the development of metabolic disorders such as hyperlipidemia, insulin resistance, type 2 diabetes, non-alcoholic fatty liver, and cardiovascular disease. In this study, we evaluated the inhibition of adipogenesis in 3T3-L1 cells and in high-fat diet (HFD)-induced obese mice by Peucedanum japonicum Thunberg L. water extract (PJT). Lipid accumulation measurement indicates that PJT markedly inhibited adipogenesis in a dose-dependent manner. RT-PCR results demonstrated that the mRNA expression of adipogenic transcription factors such as peroxisome proliferator-activated receptor-γ (PPARγ) and CCAAT/enhancer binding protein- α (C/EBPα) in 3T3-L1 cells were significantly down-regulated by PJT treatment. Oral administration of PJT (100, 300, and 500 ㎎/㎏, b.w/daily for 4 weeks) was conducted in high-fat diet induced obese mice and C57BL/6 mice. The PJT-administered group of HFD-induced mice had a lower body weight gain, along with decreased serum levels of glucose, triglycerides, and total cholesterol compared with the control mice, however, the HDL-cholesterol/total cholesterol ratio was increased. Furthermore, the elevated mRNA expression levels of adipogenesis related genes in the white adipose tissue of obese mice were significantly suppressed by PJT. These results indicate that PJT exhibits anti-obesity effects in obese mice by decreasing in serum lipid levels and lipogenesis related gene.

저자
  • 정호경(전남한방산업진흥원) | Ho-Kyung Jung (Jeollanamdo Development Institute of Korean Traditional Medicine)
  • 심미옥(전남한방산업진흥원) | Mi-Ok Sim (Jeollanamdo Development Institute of Korean Traditional Medicine)
  • 장지훈(전남한방산업진흥원) | Ji-Hun Jang (Jeollanamdo Development Institute of Korean Traditional Medicine)
  • 김태묵(전남한방산업진흥원) | Tae-Muk Kim (Jeollanamdo Development Institute of Korean Traditional Medicine)
  • 안병관(전남한방산업진흥원) | Byeong-Kwan An (Jeollanamdo Development Institute of Korean Traditional Medicine)
  • 김민석(전남한방산업진흥원) | Min-Suk Kim (Jeollanamdo Development Institute of Korean Traditional Medicine)
  • 정원석(전남한방산업진흥원) | Won Seok Jung (Jeollanamdo Development Institute of Korean Traditional Medicine) Corresponding author