본 연구에서는 스트렙토조토신(Streptozotocin,STZ)으로 유발된 당뇨쥐에게 맥문동(Liriope platyphylla,Lp)에탄올 추출물(수율:30.7%)을 1,000mg/kg용량으로 7일간 경구 투여 후 혈청속의 혈당 함량과 당대사와 관련된 몇 몇 효소와 지질대사와 관련된 물질을 측정한 결과 혈당과 triglyceride(TG), total cholesterol의 농도는 STZ대조군과 비교하여 맥문동 투여군에서 유의적인 감소를 나타내었고, glucose-6-pase(g-6-pase)활성은 STZ 대조군과 비교하여 유의적인 감소를, glucokinase(gk)활성은 증 가를 나타내었다. 또한 hepatic glycogen 함량은 STZ대조군과 비교하여 유의적인 증가를 나타내었다. 따라서 본 실험 결과 맥문동 에탄올 추출물을 스트렙토조토신으로 유발된 당뇨쥐에 있어서 항 당뇨 성 분을 함유하고 있음을 알 수 있었다.

The ethanol extraction yield of Liriope platyphylla(Lp) was about 30.7% by extract apparatus. This study was done to investigate the carbohydrate metabolism related enzyme activities effects of Lp in streptozotocin (STZ)-induced diabetic rats. The contents of serum glucose, triglyceride (TG) were significantly decreaed in Lp treated group compared to the those of STZ-control group, also content of Total cholesterol was decreased. High density lipoprotein (HDL)-cholesterol was increased in Lp treated group. The activity of glucose-6-pase(G-6-Pase) was significantly decreased in Lp treated group. Also the activity of glucokinase(Gk) was increaed in Lp treated group. The content of hepatic glycogen was significantly increaed in Lp treated group. These results indicated that ethanol extract of Lp would have antidiabetic effect in STZ-induced diabetic rats.

• 김옥경(대진대학교 과학기술대학 식품영양학과) | Ok-Kyung Kim (Department of Food Science and Nutrition, Dae Jin University, Pochen 487-711, Korea) Corresponding author