We evaluated the larvicidal and nematicidal activities of 48 3-acylbarbituric acids analogues against the Asian tigermosquito, Aedes albopictus and the pine wood nematode, Bursaphelenchus xylophilus, organisms of increasing global concern.Among 48 3-acylbarbituric acids analogues, four compounds 10, 14d, 14g, and 19b showed >90% larvicidal activity againstAe. albopictus at 10μg/mL concentration, and one (compound 10) showed the strongest larvicidal activity against Ae. albopictus,with a LC50 value of 0.22μg/mL. Only compound 18 showed strong nematicidal activity against pine wood nematode.Most active compounds possessed similar physicochemical properties; thus, actives typically had ClogP values of around1.40-1.50 and rel-PSA values of 16-17%.

• Seon-Mi Seo(Department of Forest Sciences, College of Agriculture and Life Sciences, Seoul National University, Research Institute of Agriculture and Life Science, College of Agriculture and Life Sciences)
• Hyo-Rim Lee(Department of Forest Sciences, College of Agriculture and Life Sciences, Seoul National University, Research Institute of Agriculture and Life Science, College of Agriculture and Life Sciences)
• Ji-Eun Lee(Department of Forest Sciences, College of Agriculture and Life Sciences)
• Min-Jung Huh(Department of Forest Sciences, College of Agriculture and Life Sciences)
• Il-Kwon Park(Department of Forest Sciences, College of Agriculture and Life Sciences, Seoul National University, Research Institute of Agriculture and Life Science, College of Agriculture and Life Sciences)