The objectives of this study were to investigate the effects of PM10 and O3 concentration on the symptoms of allergic diseases. The questionnaire was used to determine whether or not symptoms of allergic diseases were present from September to October 2012. The air pollution concentration data used was the corresponding point CEM (continuous emission monitoring) data. The average concentration of PM10 was 56.09 μg/m3 in the control area, and the concentration in the exposed area was 40.44 μg/m3. In the two areas, concentration of O3 was 28.73 ppb and 28.74 ppb, respectively. The total average concentrations of PM10 and O3 were 45.66 μg/m3 and 28.73 ppb in the Gwangyang area. The rate of asthma diagnosis was higher in the control area (9.6%) than in the exposed area (4.1%), but the rate of allergy eye disease was higher in the exposed area (23.9%) than in the control area (16.5%). There was a significant difference in the symptoms of some allergic diseases when the relative concentration of PM10 and O3 were high and low.