The germline stem cells of the Drosophila ovary continuously produce eggs throughout the life- span. Intricate regulation of stemness and differentiation is critical to this continuous production. The translational regulator Nos is an intrinsic factor that is required for maintenance of stemness in germline stem cells. Nos expression is reduced in differentiating cells at the post-transcriptional level by diverse translational regulators. However, molecular mechanisms underlying Nos repression are not completely understood. Through three distinct protein-protein interaction experiments, we identified specific molecular interactions between translational regulators involved in Nos repression. Our findings suggest a model in which protein complexes assemble on the 3’ untranslated region of Nos mRNA in order to regulate Nos expression at the posttranscriptional level.

ABSTRACT
  INTRODUCTION
  MATERIALS AND METHODS
  RESULTS AND DISCUSSION
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• Sumira Malik(Hormone Research Center, School of Biological Sciences and Technology, College of Natural Sciences, Chonnam National University, Dept. of Agriculture and Forestry, Tula's Institute Dhoolkot)
• Wijeong Jang(Hormone Research Center, School of Biological Sciences and Technology, College of Natural Sciences, Chonnam National University)
• Changsoo Kim(Hormone Research Center, School of Biological Sciences and Technology, College of Natural Sciences, Chonnam National University) Corresponding Author