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pp.115-121
In order to compare the suppressive effect of quercetin and several its glycosides, such as quercitrin (quercetin-3-rhamnoside), isoquercitrin (quercetin-3-gluooside), hyperin (quercetin-3-galactoside) and rutin (quercetin-3-rhamnosyl glucoside), on the genotoxicity by Nmethyl-N-nitrosourea(MNU), in vitro sister chromatid exchange(SCE) test using mouse spleen lymphocytes and in viuo micronucleus test using mouse peripheral blood were performed. MNU-indured SCEs in vitro were not decreased by the simultaneous treatment of teat compounds. Among them, quercetin and hyperin showed significant suppressive effects at high dose(10^(-5)M). On the other hand, MNU-induced micronucleated reticulocytes(MNRETs) in vivo were aignificantly decreased with good dose-dependent manner in all compounds tested. However, there were not significant differences between quercetin aglycone and its glycosides in the suppressive effects under experimental condition of this study. These results suggest that both of queroetin aglycone and its glycosides may act as an antigenotoxic agent in vivo and may be useful as a chemopreventive agent of alkylating agent.
