Cellulose is the most useful feedstock in the world that could be used to prepare new kinds of materials, and cellulose derivatives have potential application as functional polymers. Due to the present of hydroxyl groups, cellulose is considered to be an excellent material for surface modification. Among the chemical modification method, Graft copolymerization is a well-established and commonly used technique for modification of polymer surface. In this study, sulfonated GMA-g-cellulose ion exchange fibers were synthesized by gamma-ray mutual radiation. The conversion of epoxy groups into the functional groups was investigated. Factors affecting on grafting process such as radiation dose, monomer concentration, added salt and cross-linking agent were studied.