Various bioactive substances are found in Loranthus tanakae, including quercetin 3-rhamnoside (1), kaempferol 3-rhamnoside (2), rhamnetin 3-rhamnoside (3), and rhamnocitrin 3-rhamnoside (4), which inhibit tyrosinase. These compounds are mainly found in the EtOAc fraction of L. tanakae extract and demonstrate higher rates of tyrosinase inhibition than ascorbic acid, which was used as a control. Our results suggest that L. tanakae extracts can be utilized in skin whitening cosmetics.

Abstract
 Introduction
 Materials and Methods
  Extraction and partition
  HPLC analysis of EtOAc fraction
  Purification of EtOAc extract
  Structure analysis
  Assay of mushroom tyrosinase inhibitory activity
  Statistical analysis
 Results and Discussion
  Tyrosinase inhibitory activity of solvent-fractionated layers
  Isolation of tyrosinase inhibitors from the EtOAc layers
  Identification of the isolated compounds
  Tyrosinase inhibitory activity of the isolated compounds
 References

• Woonsang Hwang(Department of Bio-Health Technology, Kangwon National University)
• Cheolson Park(Department of Bio-Health Technology, Kangwon National University)
• Jaehyun Kim(Department of Bio-Health Technology, Kangwon National University)
• In-Young Ko(Department of Medical Biotechnology, Kangwon National University, Institute of Bioscience and Biotechnology, Kangwon National University)
• Kooyeon Lee(Department of Bio-Health Technology, Kangwon National University, Institute of Bioscience and Biotechnology, Kangwon National University) Corresponding author