Toxoplasmosis is a rare but fatal opportunistic infection in immunocompromised patients such as acquired immunodeficien-cy syndrome. We report a case of toxoplasmic encephalitis in a patient with acquired immunodeficiency syndrome (AIDS). A 44-year-old Thai male presented with loss of consciousness from a day ago and fever from 14 days ago. A magnetic reso-nance imaging scan of the brain revealed multiple, variable sized ring-enhancing lesions in the cerebral hemispheres. Toxo-plasma gondii immunoglobulin G antibody was tested positive by a serologic test. We diagnosed the patient as toxoplasmic encephalitis and he received pyrimethamine and sulfadiazine. We report here a rare case of patient with toxoplasmic enceph-alitis.