Severe earthquakes can cause damage to society both socially and economically. An appropriate initial response can alleviate damage from severe earthquakes. In order to formulate an appropriate initial response, it is necessary to identify damage situations in societies; however, it is difficult to grasp this information immediately after an earthquake event. In this study, an earthquake damage assessment methodology for buildings is proposed for estimating damage situations immediately after severe earthquakes. A response spectrum database is constructed to provide response spectra at arbitrary locations from earthquake measurements immediately after the event. The fragility curves are used to estimate the damage of the buildings. Earthquake damage assessment is performed from the response spectrum database at the building scale to provide enhanced damage condition information. Earthquake damage assessment for Gyeongju city and Pohang city were conducted using the proposed methodology, when an earthquake occurred on September 12, 2016, and November 15, 2017. Results confirm that the proposed earthquake damage assessment effectively represented the earthquake damage situation in the city to decide on an appropriate initial response by providing detailed information at the building scale.