This study was carried out to investigate the toxicity of food Red No.2 in the Sprague-Dawley (SD) female rat for 4 weeks. SD rats were orally administered for 28 days, with dosage of 500, 1,000, 2,000 mg/kg/day. Animals treated with food Red No.2 did not cause any death and show any clinical signs. They did not show any significant changes of body weight, feed uptake and water consumption. There were not significantly different from the control group in urinalysis, hematological, serum biochemical value and histopathological examination. In conclusion, 4 weeks of the repetitive oral medication of food Red No.2 has resulted no alteration of toxicity according to the test materials in the group of female rats with injection of 2,000 mg/kg. Therefore, food Red No.2 was not indicated to have any toxic effect in the SD rats, when it was orally administered below the dosage 2,000 mg/kg/day for 4 weeks.

ABSTRACT
 서 론
 재료 및 방법
  시험물질의 조제
  시험동물
  투여 및 투여용량
  일반증상 관찰 및 체중 측정
  사료 및 사료섭취량 측정
  뇨검사
  혈액학적 검사
  혈액생화학적 검사
  장기중량 측정 및 병리 검사
  통계 처리
 결과 및 고찰
  체중변화
  사료섭취량 측정
  일반증상관찰
  뇨분석
  혈액학적 검사
  혈액 생화학적 검사 결과
  장기 중량 및 병리 검사 결과
 요 약
 참고문헌

• 유진곤(공주대학교 특수동물학과, Department of Companion and Laboratory Animal Science, Kongju National University) | Jin-Gon Yoo
• 정지윤(공주대학교 특수동물학과, Department of Companion and Laboratory Animal Science, Kongju National University) | Ji-Youn Jung Correspondence to