The present study was evaluated the antibacterial effect of the combination of Coptidis rhizoma, Glycyrrhiza uralensis Fischet, Schizandra chinensis and Corni Fructus(1:1:1) extracts(CGSC10). Furthermore, the effectiveness of CGSC10, sodium chlorate, and the combination of CGSC10 and sodium chlorate(CGSCS10) against E. coli O157:H7 infection was studied using ICR female mice. During the incubation period, the dose of 5, 10, and 20% CGSC10 was inhibited the growth of E. coli O157:H7 by 34.7, 60.2, and 76.4%, respectively. For 7 days after single challenge with E. coli O157:H7, forty female ICR mice were divided into four experimental groups which were administered in drinking water with saline, 10% CGSC10, 15 mM sodium chlorate, and CGSCS10, respectively. On the 3rd day, the number of E. coli O157:H7 in mouse feces was significantly decreased by administration of CGSC10, 15 mM sodium chlorate, and CGSCS10 (p < 0.001). On the 7th day-after administration, CGSC10, sodium chlorate, and CGSCS10 were decreased the number of E. coli O157:H7 by 27.1, 67.7, and 83.3%, respectively. According to the results of the present study, administration of CGSCS10 to mice can reduce the severity of E. coli O157:H7 infection. In addition, it is suggested that CGSCS10 represents a good candidate for the treatment of enteric infections in domestic animals.

ABSTRACT
 서 론
 재료 및 방법
  공시제제
  사용균주 및 배양
  항균력 시험
  실험동물
  마우스 접종 및 약제투여
  마우스 분변 중 E. coli O157:H7의 검출
  통계학적 분석
 결과 및 고찰
  항균력 시험
  마우스 분변 중 E. coli O157:H7의 검출
 감사의 글
 요 약
 참고문헌

• 차춘남(경상대학교 산업시스템공학부 공학연구원, Engineering Research Institute, Department of Industrial Systems Engineering, Gyeongsang National University) | Chun Nam Cha
• 이여은(경상대학교 보건대학원 환경보건학과, Department of Environmental Health, Graduate School of Public Health, Gyeongsang National University) | Yeo Eun Lee
• 손송이(경상대학교 수의과대학 생명과학연구소, Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University) | Song Ee Son
• 박은기(고신대학교 인문사회의학교실, Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University) | Eun Kee Park
• 최현주(인제대학교 임상병리학과, 고령자라이프디자인연구소, Elderly Life Redesign Institute, Department of Biomedical Laboratory Science, Inje University)
• 김석(경상대학교 수의과대학 생명과학연구소, Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University) | Suk Kim
• 이후장(경상대학교 수의과대학 생명과학연구소, Research Institute of Life Sciences, College of Veterinary Medicine, Gyeongsang National University) | Hu Jang Lee Correspondence to