Effective filtration ability with preventing irreversible biofilm formation might be the essential characteristic of water purification membranes. The materials used in current market still need the improvement to be more practical and durable for the high performance filtration technology. Nanofiltration, which is one of the method of water filtration, the materials for this use reguire highly defined nanostrucured morphology. In this study, we synthesized amphiphilic copolymers and blended with some homopolymers, of which the homopolymer could interact with a part of the copolymer by secondary interactions. Latet, the homopolymer was able to be removed, therefore, porous structure could be created. Also, the cell adhesion experiment of these polymer blend samples indicated anti-fouling effect of them.