Grifola frondosa is a polypore mushroom that grows in clusters of oaks. The mushroom is commonly known among English speakers as Maitake, hen of the woods, ram's head and sheep's head. It is typically found in late summer to early autumn. Maitake mushroom is used to treat cancer and also to relieve some of the side effects of chemical treatment (chemotherapy) for cancer. It is also used for HIV/AIDS, chronic fatigue syndrome(CFS), hepatitis, hay fever, diabetes, high blood pressure, high cholesterol, weight loss or control, and infertility due to a condition called polycystic ovary syndrome. We have developed log cultivation technique of Grifola frondosa to produce better quality mushrooms and have investigated annual yield characteristics. As a result of the cultivation of Maitake mushroom using oak log, ‘Yipsae1ho’ varieties showed a high yield of 16.0 kg/m2 in the first year, 15.4 kg/m2 in the second year, 9.5 kg/m2 in the third year and 4.6 kg/m2 in the fourth year. The yields were decreased annually. There was no significant difference during the first year to the third year in ‘Dabark’ varieties, but it decreased sharply to 6.2 kg/m2 in the fourth year. Between the varieties, the yield of ‘Yipsae1ho’ varieties was 45.4 kg/m2 totally, which was somewhat higher than that of ‘Darbak’ varieties, 42.6 kg/m2.