Photodynamic therapy is a non-invasive cancer therapy that has recently attracted much attention in the field of cancer treatment. This study is an experiment to observe the effect of laser dose difference in photodynamic therapy. Murine breast cancer cells, EMT6 cells, were used to generate tumor bearing mouse models. The experimental group was divided into 5 groups as control group, laser 100 J/cm2, 200 J/cm2, 300 J/cm2 and 400 J/cm2 irradiation group. Photofrin was administered intraperitoneally and after 48 hours, laser irradiated on tumor with energy 0-400 J/cm2. the tumor volume was measured with a digital caliper on day 0, day 2, day 4, day 8 and day 12. The volume of tumor after photodynamic therapy was increased in the control group, laser 100 J/cm2 irradiation group and laser 200 J/cm2 irradiation group until day 12 after irradiation. Both the laser 300 J/cm2 irradiated group and the laser 400 J/cm2 irradiated group showed a decrease in the tumor volume from 2 to 12 days after irradiation. These results suggested that treatment effect will be obtained at a dose of 300 J/cm2 or more in the experiment using the tumor bearing mouse model and photoprin.

서 론
 연구대상 및 방법
  암종 생쥐모델( Tumor Bearing Mouse Model)
  광역동 치료
  통계처리
 결 과
 고 찰
 감사의 글
 참고문헌

• 김수아(조선대학교 의과대학 산부인과학 교실) | Soo Ah Kim (Department of Obstetrics and Gynecology, College of Medicine, Chosun University, Kwangju, Korea)
• 안태규(조선대학교 의과대학 산부인과학 교실) | Tae Gyu Ahn (Department of Obstetrics and Gynecology, College of Medicine, Chosun University, Kwangju, Korea) Corresponding author