본 연구는 정량적 미생물 위해평가(Quantitative microbial risk assessment: QMRA)에 절대적으로 필요한 9종의 식중독 세균, 2종의 바이러스, 1종의 원생동물에 대한 최소 감염량(minimum infective dose)을 선정한 연구이다. 주요 식 중독 미생물들의 최소 감염량을 선정하기 위하여, 1980년부터 2012년까지 PubMed, ScienceDirect database 등에서 주요 식중독 미생물들의 최소 감염량 및 위해평가 자료 82종을 수집하였다. 수집된 자료는 메타분석(mata-analysis) 에서 사용되고 있는 relative frequency(fi, 상대빈도 값)를 계 산하여 가장 적정한 최소 감염량을 추정 및 선정하였다. 주요 식중독 미생물들의 최소 감염량은, B. cereus 105 cells/g (fi = 0.32), C. jejuni 500 cells/g (fi = 0.57), Cl. perfringens 107 cells/g (fi = 0.56), Pathogenic E. coli 중 EHEC 10 cells/ g (fi = 0.47), ETEC 108 cells/g (fi = 0.71), EPEC 106 cells/g (fi = 0.70), EIEC 106 cells/g (fi = 0.60), L. monocytogenes 102~103 cells/g (fi = 0.23), Salmonella spp. 10 cells/g (fi = 0.30), Shigella spp. 100 cells/g (fi = 0.32), S. aureus 105 cells/g (fi = 0.45), V. parahaemolyticus 106 cells/g (fi = 0.64), Hepatitis A virus 10~102 particles/g (fi = 0.33), Noro virus 10 particles/g (fi = 0.71), C. pavum 10~102 oocyst/g (fi = 0.33)으로 나타났다. 본 연구결과는 향후 국내 QMRA를 통한 위해수준 추정결과의 정확성을 향상시키는데 기여할 수 있을 것으로 기대된다.

Minimum infective dose (MID) data has been recognized as an important and absolutely needed in quantitative microbiological assessment (QMRA). In this study, we performed a comprehensive literature review and meta-analysis to better quantify this association. The meta-analysis applied a final selection of 82 published papers for total 12 species foodborne disease pathogens (bacteria 9, virus 2, and parasite 1 species) which were identified and classified based on the dose-response models related to QMRA studies from PubMed, ScienceDirect database and internet websites during 1980-2012. The main search keywords used the combination “food”, “foodborne disease pathogen”, “minimum infective dose”, and “quantitative microbiological risk assessment”. The appropriate minimum infective dose for B. cereus, C. jejuni, Cl. perfringens, Pathogenic E. coli (EHEC, ETEC, EPEC, EIEC), L. monocytogenes, Salmonella spp., Shigella spp., S. aureus, V. parahaemolyticus, Hepatitis A virus, Noro virus, and C. pavum were 105 cells/g (fi = 0.32), 500 cells/g (fi = 0.57), 107 cells/g (fi = 0.56), 10 cells/g (fi = 0.47) / 108 cells/g (fi = 0.71) / 106 cells/g (fi = 0.70) / 106 cells/g (fi = 0.60), 102~103 cells/g (fi = 0.23), 10 cells/g (fi = 0.30), 100 cells/g (fi = 0.32), 105 cells/g (fi = 0.45), 106 cells/g (fi = 0.64), 10~102 particles/g (fi = 0.33), 10 particles/g (fi = 0.71), and 10~102 oocyst/g (fi = 0.33), respectively. Therefore, these results provide the preliminary data necessary for the development of foodborne pathogens QMRA.

ABSTRACT
 연구내용 및 방법
  대상 식중독 원인균
  자료 조사 및 정리
  통계분석 및 최소 감염량 선정
 결과 및 고찰
  주요 식중독 세균
  주요 식중독 바이러스
  주요 식중독 원생동물
 요 약
 참고문헌

• 박명수(군산대학교 식품영양학과, Department of Food and Nutrition, Kunsan National University) | Myoung Su Park
• 조준일(식품의약품안전평가원 미생물과, Food Microbiology Division, National Institute of Food and Drug Safety Evaluation) | June Ill Cho
• 이순호(식품의약품안전처 식중독예방과, Foodborne Disease Prevention and Surveillance Division, Ministry of Food and Drug Safety) | Soon Ho Lee
• 박경진(대학교 식품영양학과, Department of Food and Nutrition, Kunsan National University) | Gyung Jin Bahk Correspondence to