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홍화씨 추출물의 기억력 손상 억제와 산화스트레스 억제 효과 및 serotonin 과 serotonin 유도체 성분 분석

Inhibitory Effects of Safflower Seed Extract on Memory Impairment and Oxidative Stress and the Qualitative Analyses of Serotonin and Its Derivatives in the Water Extracts

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  • URLhttps://db.koreascholar.com/Article/Detail/352140
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한국약용작물학회 (The Korean Society of Medicinal Crop Science)
초록

Background : Oxidative stress and inflammatory response are important features of the brain pathology of Alzheimer's disease. Therefore, the purpose of this study was to the antioxidant activity and biochemical characterization of safflower seed. Moreover, we investigated the impact of Safflower seed on scopolamine-induced memory impairment in mice.
Methods and Results : First, in order to determine active ingredient contents of safflower seed extract, we were carried out total phenol content and total flavonoid content analyses. As a result, dried safflower seed were found to contain 35.4 ± 0.4 ㎎·GAE/g dry weight and 45.3 ± 7.5 ㎎·NE/g dry weight in boiling water extraction. Also, the major compounds of safflower seed from HPLC analysis were identified as serotonin and serotonin derivatives [N- (p-coumaroyl)serotonin and N-feruloylserotonin]. In addition, the antioxidant activity of safflower seed showed IC50 values of 331.4 and 168.2, respectively, against DPPH and ABTS in vitro. Finally, with regard to the memory improvement activity, the administration of Safflower seed extract significantly restored memory impairments induced by scopolamine in the behavior tests such as novel object recognition and Morris water maze test.
Conclusion : The results of our study suggest that the safflower seed extract possess potent memory improvement activity and are also a good source of natural antioxidants. Further study is needed to identify the mechanism responsible for their memory improvement activity.

저자
  • 박찬흠(농촌진흥청 국립원예특작과학원 인삼특작부) | Chan Hum Park Corresponding author
  • 김민조(농촌진흥청 국립원예특작과학원 인삼특작부) | Min Jo Kim
  • 허 메이통(부산대학교 식품영양학과) | Meitong He
  • 김지현(부산대학교 식품영양학과) | Min Jo Kim
  • 양창열(농촌진흥청 국립원예특작과학원 인삼특작부) | Chang Yeol Yang
  • 조은주(부산대학교 식품영양학과) | Eun Ju Cho
  • 요코자와 타카코(도야마대학교 이학과) | Takako Yokozawa
  • 김동휘(농촌진흥청 국립원예특작과학원 인삼특작부) | Dong Hwi Kim
  • 신유수(농촌진흥청 국립원예특작과학원 인삼특작부) | Yu Su Shin