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Preclinical examination of transplantation of human melanocytes and adipose-derived stromal cells for the treatment of vitiligo
- 언어ENG
- URLhttps://db.koreascholar.com/Article/Detail/355146
Human mesenchymal stem cells are known that multipotent stromal cells have the ability to divide asymmetrically, differentiate into many tissue types, and modulate cellular fate or function. Previous reports have proved that direct or indirect effects of mesenchymal stem cells in damaged cells or tissue were able to contribute to regenerative remodeling. One of incurable diseases, vitiligo is a depigmenting skin disorder resulting from the loss of melanocytes in the epidermis. Although vitiligo is a common disorder with a frequency of 0.1~2% in population, it still remains incurable and recurrent. Up to now, various treatment methods has been available for vitiligo therapy. Especially, transplantation of melanocytes (MCs) cultured with keratinocytes (KCs) is well-known therapy in clinic. We have recently reported functional role of adipose-derived stromal cells (ASCs) could assist MCs growth and maintenance of immature MCs. Therefore, the present study investigated whether the influence of ASCs may be elevated a transplantation yield of MCs in vivo. Transplantation was accomplished by syringe injection or grafting after dermabrasion. The procedure of dermabrasion is a mechanically invasive skin planning method and may be to help settle adequate location of transplanted cells to therapy. To improve an efficacy of cell transplantation, various additives or conditions of ratio were compared in vivo. These data was concluded that mixture of MCs and ASCs in the determined condition was improved engraftments of melanocytes for patients with vitiligo.
