논문 상세보기
pp.109-116
Erectile dysfunction (ED), also known as impotence, is the inability to attain and sustain an erection firm enough to have sexual intercourse. Frequent ED may be a symptom of health problems including heart disease, obesity, alcoholism, stress, smoking, and depression, that need treatment. This study aimed to effect of complex extract (CPL) including Cornus officinalis on sexual function factor in the erectile dysfunction rat model. The erectile dysfuction rat model was induced by cimetidine (500 ㎎/㎏ in 5% ethanol, oral injection 2 weeks). Rats were oral administered with different concentration of CPL in rat erectile dysfunction model. As a results, sexual function factors (NO, cGMP) significantly improved in CPL treated groups (CPL-300, 600, 900 ㎎/㎏) compared to CON group. Serum testosterone was increased in a dose-dependent manner after CPL treatment. Furthermore, administrations of CPL restored lumen areas of the prostate in the erectile dysfunction rat model. These results indicated that CPL alleviated erectile dysfunction by increasing sexual function factor and testosterone in rat model. CPL could be used to natural treatement for erectile dysfunction. However, further study is required to identify active ingredient and its mechanism of erectile dysfunction.
서 언
재료 및 방법
실험 재료
시약
실험동물 사육 및 남성갱년기 동물모델의 유발
Nitric Oxide (NO) 농도 측정
Cyclic Guanosine Monophosphate (cGMP) 농도 측정
Testosterone level 측정
조직병리학적 평가
통계처리
결과 및 고찰
복합 추출물의 수득율
사료 섭취량, 음수량 및 체중 증가량
NO 생성에 미치는 영향
cGMP 생성에 미치는 영향
혈중 테스토스테론 농도에 미치는 영향
조직병리학적 전립선의 변화
적 요
References
