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산수유를 포함한 복합추출물이 cimetidine으로 발기부전을 유도한 동물모델에서 성기능 개선 효과 KCI 등재

Effect of Complex Extract Including Cornus officinalis on the Cimetidine/Ethanol-induced Erectile Dysfunction Model in Rats

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한국자원식물학회지 (Korean journal of plant resources)
한국자원식물학회 (The Plant Resources Society Of Korea)
초록

Erectile dysfunction (ED), also known as impotence, is the inability to attain and sustain an erection firm enough to have sexual intercourse. Frequent ED may be a symptom of health problems including heart disease, obesity, alcoholism, stress, smoking, and depression, that need treatment. This study aimed to effect of complex extract (CPL) including Cornus officinalis on sexual function factor in the erectile dysfunction rat model. The erectile dysfuction rat model was induced by cimetidine (500 ㎎/㎏ in 5% ethanol, oral injection 2 weeks). Rats were oral administered with different concentration of CPL in rat erectile dysfunction model. As a results, sexual function factors (NO, cGMP) significantly improved in CPL treated groups (CPL-300, 600, 900 ㎎/㎏) compared to CON group. Serum testosterone was increased in a dose-dependent manner after CPL treatment. Furthermore, administrations of CPL restored lumen areas of the prostate in the erectile dysfunction rat model. These results indicated that CPL alleviated erectile dysfunction by increasing sexual function factor and testosterone in rat model. CPL could be used to natural treatement for erectile dysfunction. However, further study is required to identify active ingredient and its mechanism of erectile dysfunction.

목차
Abstract
 서 언
 재료 및 방법
  실험 재료
  시약
  실험동물 사육 및 남성갱년기 동물모델의 유발
  Nitric Oxide (NO) 농도 측정
  Cyclic Guanosine Monophosphate (cGMP) 농도 측정
  Testosterone level 측정
  조직병리학적 평가
  통계처리
 결과 및 고찰
  복합 추출물의 수득율
  사료 섭취량, 음수량 및 체중 증가량
  NO 생성에 미치는 영향
  cGMP 생성에 미치는 영향
  혈중 테스토스테론 농도에 미치는 영향
  조직병리학적 전립선의 변화
 적 요
 References
저자
  • 장지훈(한약진흥재단) | Ji Hun Jang (National Development Institute of Korean Medicine)
  • 김태묵(한약진흥재단) | Tae Muk Kim (National Development Institute of Korean Medicine)
  • 심미옥(한약진흥재단) | Mi Ok Sim (National Development Institute of Korean Medicine)
  • 노종현(한약진흥재단) | Jong Hyun Nho (National Development Institute of Korean Medicine)
  • 정호경(한약진흥재단) | Ho Kyung Jung (National Development Institute of Korean Medicine)
  • 이무진(한약진흥재단) | Mu Jin Lee (National Development Institute of Korean Medicine)
  • 이기호(한약진흥재단) | Ki Ho Lee (National Development Institute of Korean Medicine)
  • 안병관(한약진흥재단) | Byeong Kwan An (National Development Institute of Korean Medicine)
  • 조현우(한약진흥재단) | Hyun Woo Cho (National Development Institute of Korean Medicine) 교신저자