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Pathological lesions and antigen localization in chicken, ducks and Japanese quail naturally infected by novel highly pathogenic avian influenza (H5N6), Korea, 2016 KCI 등재

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예방수의학회지 (Journal of Preventive Veterinary Medicine)
한국예방수의학회(구 한국수의공중보건학회) (The Korean Society of Preventive Veterinary Medicine)
초록

Epizootic HPAIV, H5N6, and H5N8 infections produced severe loss in poultry and wild birds in the Republic of Korea from 2016 to 2017. But pathological lesions and antigen distribution of the novel HPAIV H5N6 clade 2.3.4.4 in natural cases have been rarely reported. Herein, we describe the pathological lesions and antigen localization in chickens (layer and Korean native), ducks, and Japanese quail naturally infected by HPAIV H5N6. Grossly, severe reddening, swelling, and some necrotic foci, which were similar to septicemia or viremia, were observed in skin and many visceral organs including trachea, lung, liver, spleen, and pancreas. Histopathologically, pulmonary congestion and edema, as well as necrotizing hepatitis, splenitis, pancreatitis, myocarditis, and encephalitis were observed. Immunohistochemically, numerous HPAIV antigens were detected in necrotic parenchymal cells and in blood vessels of the respiratory, lymphoid, digestive, urinary, nervous, and cardiovascular systems. The results indicate that HPAIV H5N6 spread to the entire body via blood and caused severe damage throughout the entire body. The HPAI H5N6 clade 2.3.4.4 virus was isolated from samples of all four cases.

목차
Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Case histories
  Korean native chicken
  Japanese quail
  Meat ducks
  Necropsy, histopathology and immunohistochemistry
  Virus isolation and identification
 RESULTS
  Gross lesions
  Histopathology and immunohistochemistry
  Virus isolation and identification
 DISCUSSION
 REFERENCES
저자
  • Youchan Bae(Animal and Plant Quarantine Agency) Corresponding Author
  • Seongjoon Joh(Animal and Plant Quarantine Agency)
  • Seokchan Park(Animal and Plant Quarantine Agency)
  • Hyukman Kwon(Animal and Plant Quarantine Agency)
  • Younjeong Lee(Animal and Plant Quarantine Agency)
  • Eunkyoung Lee(Animal and Plant Quarantine Agency)
  • Byungmin Song(Animal and Plant Quarantine Agency)
  • Yuna Lee(Animal and Plant Quarantine Agency)
  • Gyeongbeom Heo(Animal and Plant Quarantine Agency)
  • Heesoo Lee(Animal and Plant Quarantine Agency)
  • Yongkuk Kwon(Animal and Plant Quarantine Agency)
  • Kyunghyun Lee(Animal and Plant Quarantine Agency)
  • Jihyeon Kim(Animal and Plant Quarantine Agency)