This study was conducted to examine the effect of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on morphological changes in the developing rat testis. PCB 126 (0.2㎎/㎏/week) in corn oil was weekly i.p. injected into rats from 1 to 11 weeks old. The total body weights and testicular weights were measured at 3, 6, 9 and 12 weeks, respectively. The morphological changes in the rat testes were then analyzed by light microscopy (LM) and transmission electron microscopy (TEM). The results demonstrated that PCB 126 treatment caused significant change in the ratio of testicular weight/body weight at 9 week. The treatment of PCB increased the number of pregonium cells at 3 week and it decreased spermatogenesis of the seminiferous tubules at 6 week. The results of this study suggest that PCB 126 can damage the male reproductive organ of the growing rat and that it might be associated with retardation of development of the testis.

ABSTRACT
 서 론
 재료 및 방법
  1. 실험동물 및 처리
  2. 체중 및 고환의 무게변화
  3. 조직처리 및 광학 현미경적 관찰
  4. 전자현미경적 관찰
  5. 통계처리
 결 과
  1. 체중, 고환무게, 고환/체중 비의 변화
  2. 고환의 조직학적 및 전자현미경적 변화
 고 찰
 참고문헌

• 원청길(경상대학교 수의학과 및 생명과학연구원) | Chung-Kil Won (Department of Veterinary Medicine and Research Institute of Life Science, Gyeongsang National University) Correspondence
• 김문기(경상대학교 수의학과 및 생명과학연구원) | Mun Ki Kim (Department of Veterinary Medicine and Research Institute of Life Science, Gyeongsang National University)
• 박오성(경상대학교 수의학과 및 생명과학연구원) | Oh-Sung Park (Department of Veterinary Medicine and Research Institute of Life Science, Gyeongsang National University)
• 박현수(경상대학교 수의학과 및 생명과학연구원) | Hyeon-Soo Park (Department of Veterinary Medicine and Research Institute of Life Science, Gyeongsang National University)
• 최완석(한국국제대학교 물리치료학과) | Wan Suk Choi (Department of Physicaltherapy, International University of Korea)
• 김곤섭(경상대학교 수의학과 및 생명과학연구원) | Gon-Sup Kim (Department of Veterinary Medicine and Research Institute of Life Science, Gyeongsang National University) Correspondence